- Sandwich Shop Restaurants, Fredericktown
- Satellite & Cable TV Equipment & Systems Repair & Service, Fredericktown
- Savings & Loan Associations, Fredericktown
- Savings Banks, Fredericktown
- Sawmill & Planing Mills, Fredericktown
- Sawmill Supplies & Equipment Repair, Fredericktown
- Sawmill, Paper & Woodworking Supplies, Machinery & Equipment, Fredericktown
- Scrap & Waste Machinery, Fredericktown
- Scrap & Waste Materials, Fredericktown
- Secondary Schools, Fredericktown
- Security & Surveillance System & Equipment, Fredericktown
- Security Alarm Systems - Home & Business, Fredericktown
- Security Control Systems & Monitoring, Fredericktown - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Services, Fredericktown
- Septic Tank Pumping & Cleaning, Fredericktown - Septic Systems
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- Sewing Contractors, Fredericktown
- Sewing Machines, Equipment & Supplies, Fredericktown
- Shoe Store - More, Fredericktown
- Shopping & Shopping Services, Fredericktown
- Small Appliances, Fredericktown
- Snacks & Desserts, Fredericktown
- Social Services & Welfare, Fredericktown
- Specialty Stores, Fredericktown
- Staffing & Support Services, Fredericktown
- Staircases Stairs & Railings, Fredericktown
- State Government, Fredericktown
- Steak House Restaurants, Fredericktown
- Stoves & Furnace Equipment, Fredericktown - Fittings & Repair Parts
- Submarine Sandwich Restaurants, Fredericktown
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