- Safety & Security Systems & Consultants, Holts Summit
- Sand Gravel & Aggregate, Holts Summit
- Sandwich Shop Restaurants, Holts Summit
- Scrap & Waste Materials, Holts Summit
- Secondary Schools, Holts Summit
- Security Brokers & Dealers, Holts Summit
- Sheet Metal, Holts Summit
- Sheet Metal Contractors, Holts Summit - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Holts Summit
- Shopping & Shopping Services, Holts Summit
- Siding Contractors, Holts Summit - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Snow Removal Services, Holts Summit - Snow Plow Service
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- Social Services & Welfare, Holts Summit
- Social Workers & Services, Holts Summit
- Societies & Foundation Associations, Holts Summit
- Specialty Stores, Holts Summit
- Sports Promoters & Managers, Holts Summit
- Sports Promotions & Special Events, Holts Summit
- Stocks & Bond Brokers, Holts Summit
- Stone & Rock Quarry, Holts Summit - Gravel Pit, Shale, Granite, Limestone, Crushed Rock, etc
- Stucco Stone, Holts Summit
- Submarine Sandwich Restaurants, Holts Summit
- Substance Abuse Services, Holts Summit
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