- Salvage Yards, Junk Yards & Wrecker Service, Hannibal
- Sandblasting, Hannibal - General Contractors
- Sandwich Shop Restaurants, Hannibal
- Satellite & Cable TV Equipment & Systems Repair & Service, Hannibal
- Satellite Descrambling & Programming Service, Hannibal
- Satellite Dish Antennas & Equipment Dealers, Hannibal
- Satellite TV Service, Hannibal
- Savings & Loan Associations, Hannibal
- Savings Banks, Hannibal
- Scrap & Waste Machinery, Hannibal
- Scrap & Waste Materials, Hannibal
- Screen Printing, Hannibal
- Sealants Retail, Hannibal
- Sealcoating, Hannibal - Asphalt Sealcoating & Paving
- Secondary Schools, Hannibal
- Security & Commodity Brokers, Hannibal
- Security & Surveillance System & Equipment, Hannibal
- Security Alarm Systems - Home & Business, Hannibal
- Security Brokers & Dealers, Hannibal
- Security Services, Hannibal
- Senior Citizens Service & Health Organizations, Hannibal
- Sewer & Drain Cleaning & Repair, Hannibal - Drain Cleaner & Installation Services
- Sewer Construction Contractors, Hannibal - Sewer Line, Pipe Installation & Repair Services
- Sewing Machines, Equipment & Supplies, Hannibal
- Sheet Metal, Hannibal
- Sheet Metal Contractors, Hannibal - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Hannibal
- Shirts & T-Shirts, Hannibal
- Shoe Stores, Hannibal - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Hannibal
- Siding Contractors, Hannibal - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
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- Sightseeing Tours, Hannibal
- Signs, Hannibal
- Skateboards & Equipment Shops, Hannibal - Skateboarding Supplies
- Small Appliances, Hannibal
- Snacks & Desserts, Hannibal
- Snow Removal Services, Hannibal - Snow Plow Service
- Social Services & Welfare, Hannibal
- Social Workers & Services, Hannibal
- Societies & Foundation Associations, Hannibal
- Special Education & Care, Hannibal
- Special Interest Schools Or Instruction, Hannibal
- Specialty Stores, Hannibal
- Speech & Hearing Specialists, Hannibal
- Sporting Goods Stores, Hannibal
- Sports Clubs, Hannibal
- Staffing & Support Services, Hannibal
- State Government, Hannibal
- Steak House Restaurants, Hannibal
- Steel Erection Contractors, Hannibal - Steel Erectors
- Stock & Bond Brokers & Dealers, Hannibal
- Stocks & Bond Brokers, Hannibal
- Stone & Rock Quarry, Hannibal - Gravel Pit, Shale, Granite, Limestone, Crushed Rock, etc
- Stoves & Furnace Equipment, Hannibal - Fittings & Repair Parts
- Structural Engineer, Hannibal
- Submarine Sandwich Restaurants, Hannibal
- Substance Abuse Clinics, Hannibal - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Surgical Hospitals, Hannibal - Surgical Centers
- Surveyor Services, Hannibal - Surveying Service
- Swimming Pool, Sauna & Spa Contractors, Hannibal
- Swimming Pools, Hannibal
- Swimming Pools Contractors, Hannibal - Install Inground - Above Ground Pools
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