- Sandwich Shop Restaurants, Lexington
- Seafood Restaurants, Lexington
- Secondary Schools, Lexington
- Security Brokers & Dealers, Lexington
- Senior Citizens Service & Health Organizations, Lexington
- Shopping & Shopping Services, Lexington
- Siding Contractors, Lexington - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Snacks & Desserts, Lexington
- Social Services & Welfare, Lexington
- Societies & Foundation Associations, Lexington
- Specialty Stores, Lexington
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- Spill Control Equipment & Service, Lexington
- Sporting Goods Stores, Lexington
- Staffing & Support Services, Lexington
- State Government, Lexington
- Stocks & Bond Brokers, Lexington
- Submarine Sandwich Restaurants, Lexington
- Substance Abuse Outpatient Clinics, Lexington
- Support Services, Lexington
- Surplus & Salvage Merchandise, Lexington
- Surveyor Services, Lexington - Surveying Service
- Swimming Pools, Lexington
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